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Biology
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27 Nov 2019

1. Avoiding folate deficiency during pregnancy is important as without folate

a.

The mother cannot produce sufficient levels of fatty acids
b.

Synthesis of purines and pyrimidines may be limited for the foetus
c.

The risk of SCID is greatly increased
d.

The risk of Lesch-Nyan syndrome is greatly increased

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Keith Leannon
Keith LeannonLv2
2 Jun 2019
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Related questions

How might you construct an attenuation mechanism that could beused to help regulate the synthesis of purines or pyrimidines?

Why do purine:purine and pyrimidine:pyrimidine complements not exist?

a.Because purines form 3 Hydrogen bonds and pyrimidines only 2

b.Because the anti-parallel arrangement of DNA strands prevents them.

c.If only purine:pyrimidine pairs are permitted the helix will remain uniform in width from end to end.

d.Because DNA polymerase cannot initiate strand synthesis on its own.

4. THFA is an importantcontributor to the synthesis of both purines and a specificpyrimidine. Which pyrimidine? Why does ablock in the enzyme dihydrofolate reductase (DHFR) have negativeconsequences on nucleotide biosynthesis? What othernegative consequences does this have: i.e. what other pathwaysmight be influenced? Why?

5. What distinguishes thecarbamoyl phosphate synthetase used for the urea cycle (CPS I) fromthat used for de novo pyrimidine biosynthesis (CPS II)? This shouldinclude the following characteristics: pathway, cellular location,nitrogen source, and regulation.

6. What is meant by substratechanneling? How is CPS II an example of anenzyme that utilizes this?

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