Question

Interaction between specific amino acid residues found in the two identical GF receptors is critical for their dimerization. You identified that the interactions between glutamic acid and lysine, as well as that between alanine and valine, are essential for the dimerization process

5d. Would the receptor still be able to dimerize if the original amino acid bonding pair, glutamic acid and lysine, is changed to glutamic acid and phenylalanine? Explain your answer. [4 pts]

5e. Would the receptor still be able to dimerize if the original amino acid bonding pair, alanine and valine, is changed to tryptophan and valine? Explain your answer (Hint: consider both the properties and sizes of the side chains). [4 pts]