Question

BACKGROUND

The amino acid sequence for a protein that is associated with the onset of Huntington's Disease in humans is 582 amino acids long and is provided below. This disease is autosomal dominant and results in a prolonged degeneration of nerve cells in the brain.

INSTRUCTIONS

1. For this assignment, use any method you determine most feasible (i.e. programming in MATlab, R script, Crystal Ball, Witchcraft/Hocus Pocus, etc.) to decipher the amino acid composition of this protein and answer the 15 questions associated with this protein and its associated amino acid structure.

2. You will be calculating proportions (percentages - %) for this assignment. Calculate all proportions to 1 decimal place and make sure you have rounded up or down correctly. If unsure, use a spreadsheet program such as Excel to display your proportional calculations to 1 decimal place.

3. Spelling matters (Incorrect spelling will be graded as such - incorrect).

4. There is no time limit and you have three (3) attempts at this homework with the highest grade being recorded in your gradebook.

5. Download/copy the sequence and review the questions so you can double check your numbers before proceeding through the homework.

Huntington Disease Associated Protein Amino Acid Sequence

The first amino acid below ('m') represents the amino (NH3) terminus of this protein. The last amino acid in this sequence represents the carboxy (COOH) terminus and is the very last 'c' at the bottom of this protein sequence structure. The amino acids are numbered individually across the rows (left to right) beginning from the amino terminus (#1) to the carboxy terminus (#582).

mvskreniat	hhlyqawdpv	pslspattga	lisheklllq	inperelgsm	syklgqvsih
svwlgnsitp	lreeewdeee	eeeadapaps	spptspvnsr	khragvdihs	csqfllelys
rwilpsssar	rtpailisev	vrsllvvsdl	fternqfelm	yvtltelrrv	hpsedeilaq
ylvpatckaa	avlgmdkava	epvsrllest	lrsshlpsrv	galhgilyvl	ecdllddtak
qlipvisdyl	lsnlkgiahc	vnihsqqhvl	vmcatafyli	enypldvgpe	fsasiiqmcg
vmlsgseest	psiiyhcalr	glerlllseq	lsrldaeslv	klsvdrvnvh	sphramaalg
lmltcmytgk	ekvspgrtsd	pnpaapdses	vivamervsv	lfdrirkgfp	cearvvaril
pqflddffpp	qdimnkvige	flsnqqpypq	fmatvvykvf	qtlhstgqss	mvrdwvmlsl
snftqrapva	matwslscff	vsastspwva	ailphvisrm	gkleqvdvnl	fclvatdfyr
hqieeeldrr	afqsvlevva	apgspyhrll	tclrnvhkvt	tc	CARBOXY TERMINUS

I need this decoded in order to answer the following questions:

What is the name of most abundant amino acid in this protein?

What proportion of the total amino acids in the protein does this individual amino acid represent?

NOTE: Enter your proportion to ONE decimal place (e.g. 5.9) and DO NOT include the % symbol.