Cyanide is a poisonous substance because it can bind to cytochrome c oxidase (complex iv), one of the membrane proteins found in the electron transport chain. Why would this be dangerous?

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Jamar FerryLv2

28 Sep 2018

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Related questions

19. Which of the following is a component of Succinate dehydrogenase in Electron transport chain?

A. Niacin

B. FMN

C. FAD

D. Coenzyme Q

E. Lipoic acid

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A. is bidirectional

B. goes from a high energy state to a low energy state

C. takes place in the outer mitochondrial membrane

D. are used to pump H+ into the mitochondrial matrix

21. Which of the following statements about the electron transport chain is NOT correct

A. It is located in the inner mitochondrion membrane

B. Cytochrome c accepts electrons from complex II

C. Cytochrome c oxidase (complex IV) accepts electrons from Cytochrome c

D. Complex I is called NADH dehydrogenase

E. Coenzyme Q accepts electrons from complex I and complex II

22. In the electron transport chain, the enzyme cytochrome C oxidase:

A. Uses H2O as a substrate

B. Produces HOOH as a product

C. Cannot function if oxygen is absent

D. Accepts electrons from hydrogen ions

E. Uses ADP and Pi as substrates

At high altitudes, the oxygen level in air is low. Climbers of very tall mountains risk altitude sickness, which is characterized by shortness of breath, weakness, dizziness and confusion. The early symptoms of cyanide poisoning are the same as those for altitude sickness. Cyanide binds tightly to Cytochrome c oxidase, a protein complex that is the last component of mitochondrial electron transfer chains. Cytochrome c oxidase with bound cyanide can no longer transfer electrons. Explain why cyanide poisoning starts with the same symptoms as altitude sickness.

harlequinyellowjacket376

Mitochondria Generating ATP

a) What would be the effect on ATP production of adding asubstance like 2,4-dinitrophenol(alprotonophore) that makes themitochondrial membrane leaky to protons?

b) Suppose that the gulcose supply to the cell is gratlyreduced. What would be the effect on CO2 procuction by themitochondrion?

c)Pretend that you are playing mitochondrial CSI. You find thatthe mitochondria has been poisoned and it smells distincly ofalmonds... Cyanide! Cyanide (CN-) poisons the electron transportchain by interfering with cytochrome C oxidase. Explain whathappends to the mitochondria when Cytochrome C oxidase is no longerable to function. (Hint: does it still form a prton gradient?why/how? Can it still make ATP? why/how?)