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27 Feb 2018

What molecular changes are required during the reprogramming of a skin cell to an embryonic stem (ES) cell? It may help to think about this question in reverse: what happens to a cell during development as it develops from a pluripotent cell in the embryo to a specialized differentiated skin cell with a restricted function? The answer helps to explain why somatic cell nuclear transfer and induced pluripotent stem cell generation are so inefficient.

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Trinidad Tremblay
Trinidad TremblayLv2
28 Feb 2018
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