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15 Feb 2019
Magic bullets are drugs that can beadministered on a micro local scale. In this contextadministration/binding would occur in or near the tumour byexploiting the different surface antigens that cancers expose.Basic lectures teach that a "magic bullt" drug could attach via anmAb (attached to the pro-drug) and then a conjugated enzyme cleavesor converts the pro drug to a drug. This would eliminate a lot ofside effects from chemotherapy.
Use in clinical trials. Some mAbs have startedto be used in clinical trials, almost 40 years after they werefirst proposed. My question is simply; have there been any cases ofmAbs being used as a successful treatment for any disease? If not,what makes the R&D of this drug type so difficult?
Magic bullets are drugs that can beadministered on a micro local scale. In this contextadministration/binding would occur in or near the tumour byexploiting the different surface antigens that cancers expose.Basic lectures teach that a "magic bullt" drug could attach via anmAb (attached to the pro-drug) and then a conjugated enzyme cleavesor converts the pro drug to a drug. This would eliminate a lot ofside effects from chemotherapy.
Use in clinical trials. Some mAbs have startedto be used in clinical trials, almost 40 years after they werefirst proposed. My question is simply; have there been any cases ofmAbs being used as a successful treatment for any disease? If not,what makes the R&D of this drug type so difficult?
Tod ThielLv2
16 Feb 2019
