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23 Jan 2019

QUESTION:

Milrinone is a commonly used small molecule that has been show to inhibit a liverisoform of cyclic nucleotide phosphodiesterase. The use of this molecule in cellularculture has been shown to increase hepatocyte glucose production (among other things).Given this information answer the following questions: a. What does the phosphodiesterase do in a typical hepatocyte (2 points)?
b. Explain how itâs (the phosphodiester) inhibition will alter glucagon signaling (2

points)?

c. Will Milrinone use increase or decrease F26BP levels in the cell (1 points)? Why(2 points)?

d. Finally explain how Milrinone leads to increased glucose output (2 points).

*This is a question related to the Metabolism biochemistry.

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Hubert KochLv2

23 Jan 2019

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