What has been the most effective genetic therapy found so far? And which types of tissues and body systems appear to have the greatest success rates by entering the cells rather than using traditional treatment methods?
What has been the most effective genetic therapy found so far? And which types of tissues and body systems appear to have the greatest success rates by entering the cells rather than using traditional treatment methods?
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Some people suffer from adenosine deaminase (ADA) deficiency.ADA is an enzyme necessary for the immune systems T-cells tofunction properly. Helper T-cells activate B cells which secreteantibodies which are proteins that help fight against infection.When ADA is lacking due to an autosomal recessive mutation, theimmune system is extremely impaired and afflicted individuals aresusceptible to chronic infections. There are several differenttechniques that have been utilized in an attempt to treat ADAdeficient individuals: Chelsea received a bone marrow transplantfrom her father at four months of age. His healthy cells populatedher bone marrow, replacing her defective cells with normal, healthycells that produce the needed enzyme. She is now doing quite welland has functioning T and B cells in circulation. Michael receivedADA manufactured using recombinant DNA technology. Unfortunately,the enzyme stays in the blood for only a few minutes before beingbroken down - not long enough to restore immunity. Michael hassince passed away from a fatal viral infection. Shelley wasselected for gene therapy when a bone marrow donor could not befound for her. Her T-cells were separated and treated with aretrovirus which delivered a functional ADA gene to the T-cells.These T-cells were then re-infused back in to her body. Her immunesystem gradually began to function, but the treatment had to berepeated every few weeks as the genetically altered T-cells beganto die off. Todd had gene therapy like Shelley, but it wasperformed on hematopoietic stem cells from his bone marrow ratherthan on mature, circulating T-cells. Todd soon had many normallyfunctioning T cells and antibodies circulating in his blood for thevery first time. He even grew tonsils, which are typically absentin folks with ADA deficiency. Todd's ADA activity rose to 25% ofnormal levels, enough to provide limited immunity. To date hehasn't required any additional gene therapy.
Shelley needed to repeat her treatment (gene therapy) whereTodd and Chelsea did not because:
Shelley s treatment altered only the phenotypic deficiency notthe genotypic mutation. | ||
Shelley s treatment altered the genotypic deficiency not thephenotypic mutation. | ||
Shelley s treatment involved germ-line therapy, which is moretransient. | ||
Shelley s treatment didn't activate the proper genes in herT-cells. |
1 As a result of a walking while texting accident, you have broken your nose and your doctor has prescribed painkillers to help you through this difficult time. Which of the following is most likely to occur as a result of your use of painkillers?
a | The cells in your body will start to produce more smooth endoplasmic reticulum to help metabolize the painkillers. |
b | The lysosomes in your cells will hydrolyze the painkillers before they can be effective. |
c | The Golgi apparatus will label and package the painkillers for export out of your cells. |
d | The cells in your body will start to produce more mitochondria to help metabolize the painkillers. |
2. MERFF (Myoclonic Epilepsy with Ragged Red Fibers) is a genetic condition caused by a mutation in a mitochondrial gene. A man diagnosed with this disease most likely inherited this disease from his:
a father. |
b | mother. |
c | it is equally likely that this disease came from either her mother or father. |
d | Mutations in the mitochondrial genome do not cause genetic disorders. |