All of the drug candidates listed below failed to make it to the market. Indicate point in the drug discovery/development pipeline that the drug candidates probably failed. (Options are: preclinical testing, one of the phase trials or postrelease)
1.) A cholesterol lowering drug candidate was found to lead to a serious rash in all patients tested.
2.) An anti-hypertension drug candidate was found to lower blood pressure in non-human primates but was only effective in humans at high doses.
3.) A cholesterol drug was determined to be too costly to produce in order to compete with existing drugs on the market.
4.) An anti-nausea drug was found to have a very short half-life due to rapid metabolism.
5.) An antidepressant drug candidate was found to cause severe stomach ulcers in adolescent patients.
6.) An analgesic drug candidate was found to have a therapeutic index of 1.2.
Is the answer to number 2: Phase II, and the answer to 6: Preclinical?
All of the drug candidates listed below failed to make it to the market. Indicate point in the drug discovery/development pipeline that the drug candidates probably failed. (Options are: preclinical testing, one of the phase trials or postrelease)
1.) A cholesterol lowering drug candidate was found to lead to a serious rash in all patients tested.
2.) An anti-hypertension drug candidate was found to lower blood pressure in non-human primates but was only effective in humans at high doses.
3.) A cholesterol drug was determined to be too costly to produce in order to compete with existing drugs on the market.
4.) An anti-nausea drug was found to have a very short half-life due to rapid metabolism.
5.) An antidepressant drug candidate was found to cause severe stomach ulcers in adolescent patients.
6.) An analgesic drug candidate was found to have a therapeutic index of 1.2.
Is the answer to number 2: Phase II, and the answer to 6: Preclinical?
