How does a competitive inhibitor affect KM and Vmax? How does a non-competitive inhibitor affect KM and Vmax? How does a noncompetitive inhibitor affect KM and Vmax? How would each type of competitor affect a [S] vs. v0 graph?
How does a competitive inhibitor affect KM and Vmax? How does a non-competitive inhibitor affect KM and Vmax? How does a noncompetitive inhibitor affect KM and Vmax? How would each type of competitor affect a [S] vs. v0 graph?
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A drug company develops a competitive inhibitor for enzyme E. They calibrate dosing for the drug using a highly purified solution of E, in which E has no post-translational modifications. However, E is actually phosphorylated when it is in human cells. Under which of the following conditions would the inhibitor be less effective (i.e., less inhibition) in the cells than it was using the purified solution (select all that apply)? (Hint: be sure to consider which step of the reaction a competitive inhibitor interferes with, and evaluate how each of the following would impact the effectiveness of the inhibitor.) More than one anwser may be correct.
If the phosphorylated E has a lower kcat than the non-phosphorylated E | ||
If the phosphorylated E has a higher KM than the non-phosphorylated E | ||
If the phosphorylated E has a lower KM than the non-phosphorylated E | ||
If the phosphorylated E has a higher KI than the non-phosphorylated E | ||
If the phosphorylated E has a lower KI than the non-phosphorylated E | ||
If the phosphorylated E has a higher kcat than the non-phosphorylated E |