1
answer
0
watching
52
views
pucelion43Lv1
28 Sep 2019
Glycoprotein D (gD) of Herpes Simplex Virus bind nectin-1 (a ubiquitous cell membrane receptor) at sites Tyr38, Asp215, and Arg222.
These residues and Phe223 have also been identified as major viral neutralization sites.
Identify five potential mutations that could replace these residues resulting in a change in either structure or function.
Offer an explanation through a lens of the functional groups on the amino acids for each answer.
Glycoprotein D (gD) of Herpes Simplex Virus bind nectin-1 (a ubiquitous cell membrane receptor) at sites Tyr38, Asp215, and Arg222.
These residues and Phe223 have also been identified as major viral neutralization sites.
Identify five potential mutations that could replace these residues resulting in a change in either structure or function.
Offer an explanation through a lens of the functional groups on the amino acids for each answer.
Tod ThielLv2
28 Sep 2019
