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1) Please provide 2-3 examples on how it is distributed geographically, how does it compare to malaria distribution. How does it help/hinder health care when sickle cell is considered a disease of individuals of African-descent? Followed by 1 example from an alternate point of view. (Please provide answer in paragraph form)

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Keith Leannon
Keith LeannonLv2
28 Sep 2019
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Related questions

1) Please provide 2-3 examples on what ideas support or refute the classification of diseases as race/ethnicity-based? Are there advantages or disadvantages of this classification? Followed by 1 example from an alternate point of view. (Please provide answer in paragraph form)

Q49. Which of the following is NOT true?

If a genetic disease reduces fertility and the allele thatcauses the disease offers no other advantage, the allele willlikely eventually disappear, due to natural selection.

Natural selection does not favor individuals who are homozygousfor the sickle-cell allele, because these individuals typically diebefore they are old enough to reproduce.

Individuals who are heterozygous HbA/HbS areprotected from malaria, and this is why sickle-cell diseasepersists in wetter, mosquito-prone regions in Africa.

In regions where malaria does not occur, individuals who areheterozygous HbA/HbS have a fitness advantageover those who are homozygous for the normal hemoglobin allele(HbA).

Q50. AFTER malaria is cured, the frequency of the HbSallele should decrease in regions with lots of mosquitoesbecause:

People will no longer die from sickle-cell disease in theseregions.

Having one copy of the HbS allele will no longer beadvantageous in these regions.

Natural selection will no longer act on the HbS alleleat all in these regions.

All alleles associated with genetic diseases eventuallydisappear.

Q52. If the frequency ofthe HbS allele is 0.4 in a population, what is thefrequency of the HbAallele (assuming this is atwo-allele system)?

Q53. Which of the following would be sufficient for theHardy-Weinberg equation to accurately predict genotype frequenciesfrom allele frequencies?

p + q = 1

The population is not evolving due to natural selection.

The population is not evolving due to any of the conditions thatdisrupt Hardy-Weinberg equilibrium.

The population is infinitely large.

Q54. In a village, if the proportion of individuals who havesickle-cell disease is 0.25, and the population is assumed to be atHardy-Weinberg equilibrium, what is the expected frequency of theHbS allele? (Hint: What is the genotype of people withsickle-cell disease, and how is that genotype represented in theHardy-Weinberg equation?)

0.1250.250.50.75

Q55. In the same village, what proportion of the populationshould be heterozygous HbA/HbS, according to theHardy-Weinberg equation?

Use the following passage to answer the nextthree questions.

It has been hypothesized that people who are heterozygous forthe allele that causes the deadly genetic condition cystic fibrosis(which, among other symptoms, reduces fertility) are more resistantto the deadly disease tuberculosis.

Q56. If the cystic fibrosis allele protects against tuberculosisthe same way the sickle-cell allele protects against malaria, thenwhich of the following should be true of a comparison betweenregions with and without tuberculosis?

Cystic fibrosis deaths should be more common in regions withtuberculosis.

Cystic fibrosis deaths should be less common in regions withtuberculosis.

Cystic fibrosis deaths should be equally common in both types ofregions.

Regional differences in the cystic fibrosis death rate should bepurely random and unpredictable.

Q57. A person who is heterozygous for the cystic fibrosis allelemoves to a small, isolated community where no one previouslycarried the allele. If the cystic fibrosis allele protects againsttuberculosis the same way the sickle-cell allele protects againstmalaria, what should happen to the frequency of the cystic fibrosisallele in the community over time, and why?

The cystic fibrosis allele should disappear from the population,because a single individual with the allele is not enough for it toproliferate.

The cystic fibrosis allele should increase to a relatively highfrequency, because heterozygotes with the allele will be morelikely to survive than others.

The cystic fibrosis allele should become fixed in thepopulation, due to genetic drift.

The cystic fibrosis allele should either disappear or increasein frequency, depending on chance as well as on tuberculosisprevalence and death rate.

Use the following additional passage to answer the nextquestion.

Suppose you travel to the future, to a time when neithercystic fibrosis nor tuberculosis have caused any deaths for manygenerations. In all of these future populations, thecystic fibrosis allele still exists at a low frequency.

Q58. You visit a huge city with millions of people. If you wereto start sampling the cystic fibrosis allele from one generation tothe next, what should happen to its frequency over the next fewgenerations, and why?

The allele frequency should change a lot from one generation tothe next due to random genetic drift.

The allele frequency should not change much from one generationto the next because the population is large.

The allele frequency should steadily increase due to naturalselection.

The allele frequency should steadily decrease due to naturalselection.

1. A) Explain how changes in the environment drive evolutionary change. B) Provide and explain an example

2. A) Explain how the Hardy-Weinberg equation allows us to find evidence of evolution. B) Could processes other than Natural Selection result in deviation from the Hardy-Weinberg equilibrium? List and explain each one: C) define what the process is and D) the effect it has on the allele frequency.

3. A gene that is responsible for multiple traits (pleiotropy), for example the same allele causes sickle-cell anemia and provides resistance to malaria. Would a gene that controls these two traits respond equally to natural selection favoring malaria resistance as a non-pleitropic gene that only controls malaria resistance? Explain your answer.

4. A) Explain how lack of genetic variation limits evolution and provide an example. B) Explain how epistasis limits evolution and provide an example

Questions 5-6 are based on the following:

Let’s say you are studying a population of Japanese four o’clock plants. In these plants, the allele for red color flower shows incomplete dominance over the allele for white flowers. This is very convenient for this experiment because you can distinguish the heterozygous (pink flowers) from the homozygous dominant (red flowers). For your experiment, you produced a large number of plants, 25% had red flowers, 25% had white flowers and 50% had pink flowers. You transplanted them into different habitats and left some in the lab (using the same proportions in all the habitats). You waited a few years, while plants reproduce for a few generations and then you go back and resample the populations you’ve transplanted.

5. In the lab you ensured that all individuals receive all requirements to grow and reproduce and mate randomly. A) What do you expect the distribution of the phenotypes after a few generations breeding in the lab? B) Is the lab population in Hardy-Weinberg equilibrium? Yes/No, explain

6. In habitat A, you find that you only have red flowering plants and white flowering plants but there are no pink flowering plants. A) Is the population in habitat A in Hardy-Weinberg equilibrium? Yes/No, explain. B) Which one(s) of the five agents of evolutionary change could be responsible for these results? Explain. C) What type(s) of selection (stabilizing, disruptive, directional, oscillating, etc...) could be responsible for the results in habitat A? Explain

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