The EGF-receptor is a receptor tyrosine kinase that binds toepidermal growth factor (EGF). In response to EGF binding, theEGF-receptor stimulates a signaling pathway that involves Ras.Ultimately, this signaling pathway leads to the upregulation offactors that promote cell division. As a result, in response toEGF, cells that express the EGF-receptor undergo cell division toproduce more cells. If an inhibitor that inhibited all G proteinswas added to cells, how would this affect the ability of thesecells to respond to EGF?
1)The inhibitor would have no effect, because the EGF-receptoris not a G protein-coupled receptor.
2)While the receptor would dimerize and autophosphorylate in thepresence of the inhibitor, downstream signaling would be preventedbecause the inhibitor would affect Ras activity.
3)In the presence of the inhibitor, the receptor could bind toEGF and dimerize, but it would not be able to autophosphorylatebecause this requires the activity of a G protein.
The EGF-receptor is a receptor tyrosine kinase that binds toepidermal growth factor (EGF). In response to EGF binding, theEGF-receptor stimulates a signaling pathway that involves Ras.Ultimately, this signaling pathway leads to the upregulation offactors that promote cell division. As a result, in response toEGF, cells that express the EGF-receptor undergo cell division toproduce more cells. If an inhibitor that inhibited all G proteinswas added to cells, how would this affect the ability of thesecells to respond to EGF?
1)The inhibitor would have no effect, because the EGF-receptoris not a G protein-coupled receptor.
2)While the receptor would dimerize and autophosphorylate in thepresence of the inhibitor, downstream signaling would be preventedbecause the inhibitor would affect Ras activity.
3)In the presence of the inhibitor, the receptor could bind toEGF and dimerize, but it would not be able to autophosphorylatebecause this requires the activity of a G protein.
