1- The drug chloroquine raises the pH of endosomes, How willthis affect antigen processing and presentation by class IIMHC?
2- A common approach to vaccine development has been the use ofa viral vector such as vaccinia virus to carry genetic informationof a pathogen into an individual. The vaccinia virus infection(which does not cause disease in most individuals) would then leadto production of proteins from the pathogen and an immune response.Such an approach has been very successful for viruses but has notbeen successful for most bacterial infections. Why?
3- The pathogen Listeria monocytogenes enters cellsthrough phagocytosis but escapes from the phagosome before it isdestroyed. Would patients who are deficient in class I MHC bebetter or worse hosts for this pathogen than normal individuals?Why?
1- The drug chloroquine raises the pH of endosomes, How willthis affect antigen processing and presentation by class IIMHC?
2- A common approach to vaccine development has been the use ofa viral vector such as vaccinia virus to carry genetic informationof a pathogen into an individual. The vaccinia virus infection(which does not cause disease in most individuals) would then leadto production of proteins from the pathogen and an immune response.Such an approach has been very successful for viruses but has notbeen successful for most bacterial infections. Why?
3- The pathogen Listeria monocytogenes enters cellsthrough phagocytosis but escapes from the phagosome before it isdestroyed. Would patients who are deficient in class I MHC bebetter or worse hosts for this pathogen than normal individuals?Why?
