Question

Currently, most drugs either inhibit the synthesis of prostaglandins/leukotrienes (cyclo-oxygenase inhibitors) or they inhibit transcription of genes encoding inflammatory cytokines (such as IL-1, TNF-beta) (glucacorticoids). present some ideas for new targets for anti-inflammatory drugs that will work by inhibiting extravasation of macrophages, neutrophils, or TH1 cells. Explain the reason choosing a particular target. Then, explain what the target does and explain why inhibiting it will have the effect you expect. Also briefly discuss about possible adverse effects-would the drug cause increased susceptibility to new infections, for example.