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MHC I & MHC II serve different purposes in the body. Discuss, in detail, what might go wrong if each system were to fail. In other words, list potential problems that may arise from failure of the MHC I system and compare/contrast that with the problems that would arise from failure of the MHC II system.
Most individuals with Down syndrome arise from non-disjunction in the parents. However, Down syndrome can also arise in the offspring of chromosome 14-21 translocation heterozygotes. What are the possible gametes produced by a person who is a translocation heterozygote for chromosome 14-21? Which ones result in non-viable progeny, and why?