What experiment could be performed to ascertain if an antimicrobialagent is bactericidal or bacteriostatic? Can a bacteriostatic agentbecome bactericidal in the long run or vice versa? Why?
What experiment could be performed to ascertain if an antimicrobialagent is bactericidal or bacteriostatic? Can a bacteriostatic agentbecome bactericidal in the long run or vice versa? Why?
Related textbook solutions
Related questions
Recognize the following major structures and know how changing the structure will effect the activity (if we discuss any):
Penicillins, Cephalosporins
1. What is the mechanism of action for penicillins and cephalosporins? Is it bactericidal or bacteriostatic? What are the side effects?
2. What is the common structural feature of all penicillins and which is the functional group that is modified?
3. What are the common problems associated with natural pencillins?
4. What does hypersensitivity have to do with chemical reactivity?
5. What is the major mechanism for resistance with the penicillins? List two other mechanisms.
6. What is the structural change that we make to instill beta lactamase resistance? This reduces the activity of these penicillins, what are the three undesirable characteristics. Consider nafcillin as the prototypes. What advantage do oxacillin & dicloxacillin have over nafcillin?
7. What is the normal spectrum of susceptible organisms for pen V, limited (methicillin), broad (ampicillin) and extended (carbenicillin) spectrum penicillins?
| Class/Spectrum | Gram (+) coverage | Gram (-) coverage | Beta-lactamase resistant | other |
| Pen V/traditional | + | - (weak) | - | |
| Methacillin-like/limited or narrow | ||||
| Carbenicillin/extended | Inc. pseudomonas | |||
| Ampicillin/Broad |
