BIOL 522 Lecture Notes - Lecture 5: Fine Structure, Linkage Disequilibrium, Haplotype
Document Summary
6,000 people for source-like populations included native americans , 12000 americans were probably admixed americans. Globetrotter , fine structure, browning ibd (identity by descent)= family of algorithms, based on same model. Identity by descent = share long chunks of chromosome to be considered as ibd, haplotypes have to be phased/ matched/ in phase with other people"s. There were discrete populations with noticeably different/ distinguishable features, mixed to make variety of individuals - what % of population comes from different sources. Stretch of dna with several alleles glued together inherited at once - relative contributions of ancestors determine how often this stretch gets inherited. Relative contributions of different local ancestries gives you a lot of info about adaptation. Fine structure is almost too structured - prof tishkoff"s data showed 14 colours because they mate with each others more than with other groups/ share more haplotypes, so each ethnic group have their own cluster.
