BIOL 522 Lecture Notes - Lecture 12: Effective Population Size, Linkage Disequilibrium, Genetic Architecture
Document Summary
Genomics of disease risks in globally diverse populations. Gwas = hypothesis free of association between genetic variants and quantitative traits or diseases, associations are examined across the whole genome using genotypic array or sequencing approaches. How current gwas are biased towards populations from european descent. What portion of the 915 studies published from 2005-2016 are based on which populations/ ancestry, biggest fold change is in hispanic latin american and greater middle eastern population. Most studies are done in europeans in gwas. Forms backdrop that since large portion of studies and populations are european, so methods formed on the basis of these gwas studies are more useful for european studies than other populations less ld - linkage. Number of signif associations increased in africans coz of more diversity, disequilibrium decays faster in africans (this leads to more associations because, wider peak/ lds in. Europeans, so you only see associations to a narrower region, fine mapping), have larger effective population size,
