MCD BIO 165A Lecture Notes - Lecture 16: Dnm1L, Atp Synthase, Voltage-Dependent Anion Channel
15 Dec 2016
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Document Summary
Er has role in regulating division of mito. #/size of mito: depends on energy requirement of cell. Outer membrane: 50% protein, 50% lipids, porins, form pores, high permeability, very selectively permeable. Inner boundary membrane: 75%+ protein, atp synthase, etc transport chain, cardiolipin. Evidence of ancestry: no cholesterol, bc cholesterol would cause lack in motility impermeable, cristae, machinery for atp synthesis here. Mito matrix: circular dna, codes for 13 mrna -> mito proteins, trna, 2 rrna, evidence of ancestry, ribosomes. Porin: beta sheet barrel, allows moderate sized molecules to pass, critical for intake of molecules involved in respiration. Splitting into two mito: determines amt/length/degree of interconnection. Ip3 in er interacts w/ vdac in mito. Mito only uptakes unfolded proteins: chaperones unfold and refold once inside. Protein enters thru tom complex (protein import complex: receptor and channel on outer mito membrane. Protein enters thru tim complex to get into inner mito membrane.
