CHEM 3050 Lecture Notes - Lecture 37: Competitive Inhibition

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CHEM 3050
Lecture 37
There is no change in catalysis. The amount
of product we make will eventually be the
same if we can outnumber the amount of
substrate. However, it does influences
relative substrate affinity which causes an
increase in Km known as the apparent
KM = αKM.
α = 1+ [I]/ KI
More inhibitor (I) increase in α thus
less KI
Vmax is still the same, slope is different
Y-int is not affected the x-int is affected
Increase in [I] increase in slope
decreasing the x-axis
Km increases directly with [I] Km
increases inversely with KI
o KI = the measure of the enzyme’s affinity for
the inhibitor, also tells us the strength of the
potential inhibitors
Lower the KI, there is a decrease in the
affinity of the substrate
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