PHAR 100 Lecture Notes - Lecture 5: Adverse Drug Reaction, Combined Oral Contraceptive Pill, Drug Allergy

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Nikki Philbrook

Document Summary

List major substances involved in and steps to minimize accidental child poisoning. List reasons why drug toxicity in humans is difficult to predict from animal studies. Types of adverse effects: extension of therapeutic effect: a drug becomes toxic because too much of the drug is in the blood. Benzodiazepine is a sedative but over dose produces over sedation. An anticoagulant over dose will cause bleeding: unrelated to main drug action: drug-receptor interaction in tissues other than the site of action. Digitalis, designed to strengthen the heart muscle may also cause nausea, abnormal colour vision: idiosyncrasy: due to an unusual genetic makeup in an individual. The next time the drug is given, the antigen-antibody combination provokes an adverse reaction in the patient: drug dependence and addiction: Dependence: abnormal physiological state that is produced by repeated administration of a drug and that results in withdrawal when it is not taken.