PHAR 100 Lecture Notes - Lecture 19: Coronary Artery Disease, Coronary Circulation, Transdermal Patch

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Bill Racz

Document Summary

Coronary artery disease (cad) = narrowing or blocking of coronary arteries which leads to a decreased blood flow and thus decreased oxygen to the heart. Controllable: obesity, physical inactivity, smoking, hypertension, atherosclerosis, diabetes mellitus. Manifestations of cad: asymptomatic, angina pectoralis sudden onset of heart pain due to myocardial ischemia (decreased o2 to heart). Precipitating factors include exertion, stress, heavy meals, cold weather. Relax smooth muscle of blood vessel = vasodilation: venous dilation (decreased venous return = decreased cardiac output = decreased myocardial work= decreased myocardial o2 demand= decreased heart size). Coronary dilation (increased blood supply to the heart = increased perfusion = increased ability of o2 to supply ischemic myocardium). Arterial dilation (decreased peripheral resistance = decreased blood pressure). Calcium channel blockers (cid:271)oth of these are for slo(cid:449) a(cid:272)ti(cid:374)g pre(cid:448)e(cid:374)tio(cid:374: myocardial infarction, death. Forms and side effects of anti angina drugs: Possible headache, flushing, hypotension, tachycardia, dizziness, tolerance (increase dose = more side effects).