PHAR 100 Study Guide - Final Guide: Isosorbide Dinitrate, Coronary Artery Disease, Calcium Channel Blocker

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Jeanne Mulder, William Racz

Document Summary

Lesson 4. 1: drugs for the treatment of angina pectoris: most common condition resulting from ishemic heart disease. History amyl nitrite rst introduced by lauder brunton; administered by inhalation but re ief only lasted 3-5 minutes improvements were made by william murrell who introduced sublingual nitroglycerin; lasted 20-30 minutes. Classes of drugs: organic nitrates: short-acting nitroglycerin & long-acting isosorbide dinitrate, beta-adrenergic antagonists: propranolol, calcium channel blockers: nifedipine. Mechanism of action of organic nitrates relax the smooth muscle of blood vessels through: relaxation of large capacitance vessels, leading to vasodilation resulting decrease in blood returning to heart, cardiac output, heart size, and blood pressure. Decreased energy expend and oxygen requirement: dilation of large coronary arteries. 1) termination of individual attack acts in about 2 minutes (sublingual) and relief of pain is sudden & complete: prevention of individual attack. Protective e ect against angina lasts for about 30 minutes during which time exercise can be undertaken: chronic prophylaxis.