HTHSCI 2H03 Lecture Notes - Lecture 9: Ipratropium Bromide, Salbutamol, Theophylline
29 Apr 2016
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Document Summary
Bronchioles contain smooth muscle that responds to inputs from the ans. Sympathetic input stimulates beta2-adrenergic receptors, relaxes bronchiole smooth muscle and increases lumen diameter, bronchodilation. Anatomy of the respiratory system offers a unique opportunity for targeting tissues pharmacologically. Small particles of liquid or ne solid particles. Masks that go over the nose and the mouth. Used when people are taking small shallow breaths. Use a propellant to deliver medication into the lungs. Terminate the asthma attack by inhibiting bronchospasm. Twitchy , bronchioles narrow easily in response to stimuli such as cold air, exercise, chemical mediators (histamine, methacholine) Abnormally high levels of in ammatory cells: lymphocytes, eosinophils, mast cells. Prevention therapy (anti-in ammatory) and relief therapy (bronchodilators) act to: Block the production of chemical mediators of asthma. Block or inhibit the action of the chemical mediators of asthma. Corticosteroids also inhibit the synthesis of cox-2. Daily administration suppresses airway in ammation, reduces airway hyper-responsiveness and airway obstruction, preventing asthma attacks.
