HTHSCI 2H03 Lecture Notes - Lecture 25: Beta-Adrenergic Agonist, Nebulizer, Omalizumab
21 Jul 2017
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Document Summary
Sympathetic input stimulates responds to inputs from the ans beta 2 -adrenergic receptors, relaxes bronchial smooth muscle and increases lumen diameter, bronchodilation. If cox 1 and cox 2 are inhibited the arachidonic acid will be converted into leukotrienes and constrict bronchioles. Increased levels of inflammation and immune cells. Bronchioles narrow easily in response to stimuli such as cold air, exercise, chemical mediators. Massive recruitment of immune and inflammation and can cause airway remodelling. Reduce intensity & frequency of asthma symptoms. Reduce symptoms of asthma (cough, chest tightness, wheezing, Reduce need ( 2 days per week) for short acting beta agonists. Reduce the risk of adverse effects associated with asthma. Prevention of recurrent exacerbations and need for emergency department or hospital care. Prevention of reduced lung growth in children, and loss of lung function in adults. Optimization of pharmacotherapy with minimal or no adverse effects. Glucocorticoids have less side effects if they are in a inhaled form.
