MIMM 214 Lecture Notes - Lecture 19: Fas Ligand, Cytotoxic T Cell, Follicular B Helper T Cells
17 Feb 2017
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Document Summary
Cytokine patterns and cross-regulation; chemokines, receptors & homing. Successful t cell-apc interactions organise signaling molecules into an immunological synapse. Tcr/pmhc complexes and coreceptors centralise: central supramolecular activating complex = csmac. Adhesion molecules/bound ligands peripherally localise: peripheral supramolecular activating complex = psmac. If you stain the immunological synapse, you can see that there is a differentiation between the central and peripheral parts of the interaction very tight interaction. Clustering of many different tcr:pmhc complexes with cors as well as costimulatory molecules in the center of this interaction = csmac psmac consists of a series of adhesion molecules and bound ligands. The initial interaction between t cells and apcs, it is mediated by adhesion molecules. Both get expressed on the surface of effector r cells and are crucial for their fxn. Expressed by effector cd8+ cells and th1 cells. Used by cd8+ t cells to exert cytotoxic effect. Expressed by th1, th2, th17 and tfh cells.
