MIMM 214 Lecture Notes - Lecture 18: Interleukin 10, Transforming Growth Factor Beta, Interleukin 4
7 Jun 2018
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Lecture 19 – February 15, 2017
Immunological Synapse
Immunological synapse
- Successful T cell-APC interactions organize signaling molecules into an immunological synapse
o TCR/MHC-peptide complexes and coreceptors centralize
▪ Central supramolecular activating complex
▪ Clustering of many different TCR/MHC-peptide complexes
o Adhesion molecules/bound ligands peripherally localize
▪ Peripheral supramolecular activating complex, pSMAC
FAS Ligand and CD40 Ligand
Fas ligand & CD40 ligand
- Both get expressed on the surface of effector T cells and are crucial for their function
- Membrane bound ligands, part of TNF family
- Their expression is regulated
- Fas ligand
o Expressed by effector CD8+ cells and Th1 cells
o Binds Fas on infected cells
o Used by CD8+ T cells to exert cytotoxic effect
- CD40
o Expressed by Th1, Th2, Th17, Tfh cells
o Binds cD40 on B cells and innate immune cells
o Used to activate these target cells
T cell subtypes and Cytokine Patterns
Effector T cells
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- Induces signaling through STAT proteins
- Transcription factors
o Induce genes of transcription factors
- Function of T cell subtypes
find more resources at oneclass.com
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Document Summary
Successful t cell-apc interactions organize signaling molecules into an immunological synapse: tcr/mhc-peptide complexes and coreceptors centralize, central supramolecular activating complex, clustering of many different tcr/mhc-peptide complexes, adhesion molecules/bound ligands peripherally localize, peripheral supramolecular activating complex, psmac. Both get expressed on the surface of effector t cells and are crucial for their function. Membrane bound ligands, part of tnf family. Fas ligand: expressed by effector cd8+ cells and th1 cells, binds fas on infected cells, used by cd8+ t cells to exert cytotoxic effect. Cd40: expressed by th1, th2, th17, tfh cells, binds cd40 on b cells and innate immune cells, used to activate these target cells. Th1 responses are often involved in the response to infections by viruse and pathogens that survive inside macrophage vesicles. Th2 responses are often involved in the response to parasites and other extracellular pathogens (and also allergy) Th17 responses are often involved in the response to infections by extracellular bacteria and fungi.
