BIOL 101 Chapter Notes - Chapter 5: Point Mutation, Pyrimidine Dimer, Dna Replication

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23 Mar 2018
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Mutation: a change in an organism"s dna sequence. Mutation rate: the number of mutational events in a given gene per generation. Usually very low (many mechanisms in place to prevent them) Cells get stuck in small blood vessels, block blood flow. Chemical changes to nucleotides that are not correctly repaired. Ex: loss of a base from its nucleotide. Creates a gap/hole in the dna where a base should be. If gaps are not repaired before the next dna replication, dna. Abnormal sickle shape of red blood cells in low oxygen conditions. Can lead to organ damage and shortened lifespan. Usually only changes one amino acid in the final protein. May or may not seriously affect the protein"s function. Sickle cell anemia: caused by a single substitution in the hemoglobin gene. Substitution mutation: one base-pair is substituted for another. Frame-shift mutation: insertions or deletions add or remove a base pair; all codons after the mutation are altered.

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