BIOCHEM 423 Chapter Notes - Chapter 7.10: Cooperative Binding, Hemoglobin, Hydrogen Bond

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The pole of conformational change in oxygen transport a cooperative binding and ahostery. Higher animals use 02 . binding proteins to transport 02 from lungs or gills to respiring tissues where it is needed to support metabolism . a hemoglobin. 100 mmhg , nearly saturated a efficiency in. 02 transport is achieved by cooperative binding in multisite proteins , described by a sigmoid at binding site - strong . Weak binding a cooperatively ligand binding to the first empty site somehow increases the 02 - binding attimty of the remaining sites . held communication between binding sites a hill coettiaeut in. H : related to the number of ligand - binding sites in ) and the energy of their interaction , such that the value of he approaches the value a as the interaction between sites increases. A models for the atlostenc change in hemoglobin a sequential models.

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