BIOCHEM 423 Chapter Notes - Chapter 8: Uncompetitive Inhibitor, Ace Inhibitor, Statius
7 Dec 2018
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Inhibition reversible inhibitors non - covalent binding of the inhibitor irreversible inhibitors covalent binding of the inhibitor a competitive inhibition. Inhibitors compete with substrates for binding to the same site on the enzyme ] a. Addition of inhibitor decreases the velocity but not vmax . Km is higher in the presence of inhibitor . v= Some competitive inhibitors are used to treat human disease . Statius inhibit an enzyme critical for the synthesis of cholesterol s ace inhibitors are prescribed to treat hypertension . For an enzyme inhibitor to be eteuive therapeutic , it must bind its target specifically and with a k that indnmoarorwwr a figure. Inhibition uncompetitive inhibitors bind tightly to the es complex but shows low or an attinity for the free enzyme. C an anticancer agent ) and mywphenolic and. Lan anti rejection , or immunosuppressive , agents are uncompetitive inhibitors of their target enzymes . a.
