BIOCHEM 420 Chapter Notes - Chapter 6: Conformational Entropy, Random Coil, Thermodynamics

12 views4 pages

Document Summary

Denaturation : loss of tertiary and secondary structure so that the polymer becomes two strands (cid:8869) can be induced by heating and by certain changes in chemical environment. * amino acid sequence (primary structure) determines secondary and tertiary structure. Protein can self - assemble into its functional conformation , and it needs no information to guide it other than that contained in its amino acid sequence. The overall free energy change for folding must be negative (cid:8869) negative free energy change is achieved by a balance of thermodynamic factors several. Random coil (higher entropy) folding protein (lower entropy) Free energy equation , dg =d h - t d s. , shows that a negative as makes a positive contribution to sg (cid:8869) conformational entropy change works against folding. * the decrease in conformational entropy when a protein folds disfavors folding (cid:8869) this is compensated in part by energy stabilization through internal non covalent bonding charge - charge interactions.

Get access

Grade+
$40 USD/m
Billed monthly
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
10 Verified Answers
Class+
$30 USD/m
Billed monthly
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
7 Verified Answers

Related textbook solutions

Related Documents

Related Questions