AH 3121 Chapter Notes - Chapter 9: Microorganism, Fas Ligand, Foxp3
Document Summary
Apecep: autoimmune polyendocrinopathy with candidiasis & ectodermal dysplasia. Mouth, genitals, other moist areas (skin folds), armpits, etc: inheritance of 2 defective aire alleles (rare) Genetic predisposition in finns, sardinians, iranian jews. Super common in some areas of the world but almost unheard of in others: childhood development of autoimmune b and t cell responses against. Most endocrine glands: patients suffer from a variety of autoimmune diseases, all suffer from candidiasis (yeast infection) Ectodermal dystrophy: abnormalities of teeth, hair, and fingernails. Induction of peripheral tolerance: mature t cells recognize self ag in peripheral tissues too strongly. Self-reactive cells are suppressed by t regulatory cells. If they just bind to self-ag, nothing really happens. Signal 1 foreign antigen presented w/ mhc molecule; binds. Signal 2 costimulators expressed on apcs in response to microbes (ie. b7) Because they have the right receptor to go after the microbe: anergic response.
