AH 3121 Chapter Notes - Chapter 7: Epitope, Cell Nucleus, Follicular Dendritic Cells
Document Summary
Stimulated by different cytokines from helper t cells. Caused by inactivating mutations in the cd40l gene on the x chromosome. Almost all serum ab is igm due to defective heavy chain class switching. Patients have defective cell-mediated immunity against intracellular microbes. This is a rare, genetic immune deficiency disorder. B cells do not need helper t cell stimulation. Igg subclasses (igg1, igg3) fc receptor dependent phagocyte responses; complement activation; neonatal immunity via placental transfer. Is best for opsonization (coating bacteria with ab to be phagocytosed) Ige immunity against helminths and mast cell degranulation (immediate hypersensitivity) Coats helminths which are eliminated by eosinophils that bind ige. Often the eggs of helminths what causes the pathology. Iga mucosal immunity (transport of iga through epithelia) First defense against intestinal microbes due to its ability to bind to mucus of epithelial tissues. Heavy chain class determined by helper t cell-produced cytokines. Secreted through mucosal epithelia: affinity maturation.
