AH 3121 Chapter Notes - Chapter 5: T Helper Cell, Sarcoma, Cytosol
Document Summary
Secrete cytokines, especially il-12: t cells that bind to ag without costimulation mean they are anergic (functionally inactivated without being killed; not actively killed and nonfunctional) May be a means of preventing autoimmunity: other roles for costimulators. Eliciting a t cell response: not all proteins are able to elicit a t cell response on their own. Vaccines: require administration of additional substances that activate macrophages and other apcs. Increase accumulation of apcs at site of antigen exposure) usually via injection. Increase expression of costimulators and cytokines by apcs. Enhance the immune response to the ag without eliciting an immune response to itself. Has to be coupled with antigen/bacterial toxin to elicit a response. Avery welch ah 3121 immunology week 4 chapter 5 notes 9/22/15-/9/24/15. Only adjuvant licensed for vaccine use in the us. Stimulate b cells to increase antibody response.
