BMB 401 Chapter Notes - Chapter 4: Citric Acid Cycle, Nadh Dehydrogenase, Isocitrate Dehydrogenase
Document Summary
Tca cycle- wants to generate nadh and fadh2 to go into electron transport chain. Pdh complex- oxidative decarboxylation which create acetyl coa for the tca cycle to start. Coenzymes: tpp, lipoamide, coenzyme a, fad, nad (b1, b2, b3, b5, and lipoic acid) Regulation: controlled by its own pdh kinase- starving you will turn this off through the kinase and turn it on when atp is needed using the phosphatase (exercise, after a meal) Regulation- adp turns it on, atp, nadh, fadh2 turn it on (products) Oxidative phosphorylation- occurs in the inner membrane of the mitochondria. Coenzyme q takes h+ from nadh in complex one and transfers the nad to complex iii. Shuffles the nad using cyto c to complex iv. O2 gas passes through this and is reduced and split into water. Complex ii- is the succinate dehydrogenase in the tca cycle. Reconverts fadh2 to fad by taking its 2 h+