BSC 114 Chapter Notes - Chapter 2-6: Lysosome, Exocytosis

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Endomembrane System
Endoplasmic Reticulum
Transports proteins and lipids
Smooth ER
No ribosomes
Site of lipid synthesis
Rough ER
Has ribosomes
Think about proteins
Site of protein synthesis
Proteins exit the RER out of the lumen via Exocytosis
Lumen forms a vesicle that provides an exit for the proteins
Lysosomes then take charge and direct the proteins once out of the RER
Lysosomes
Carry out a couple of functions
Directing proteins
“Safety patrol”
After proteins exit the RER, lysosomes take charge
Point proteins to the Golgi cis opening
Cis: front or beginning
Golgi Apparatus
Most jobs of any
Sorts, modifies, and packages proteins
Proteins enter golgi via endocytosis
Once inside, lysosomes in the golgi point proteins depending on their function
This is the sorting of the proteins
Once sorted, golgi enzymes modify the proteins
Golgi enzymes methylate, demethylate, add phosphate, etc to make sure
that they are what they should be depending on what the proteins need to
do
Once modified, they leave through the trans exit
Exit via exocytosis
When proteins leave the golgi, they are in their permanent vesicle coating
Now the proteins go to wherever their function is
Whole process
RER → Lumen → Lysosomes → Golgi (through cis opening) → Lysosomes sort →
Enzymes modify → Packaged → leave golgi → goes to their various functions
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Document Summary

Proteins exit the rer out of the lumen via exocytosis. Lumen forms a vesicle that provides an exit for the proteins. Lysosomes then take charge and direct the proteins once out of the rer. After proteins exit the rer, lysosomes take charge. Point proteins to the golgi cis opening. Once inside, lysosomes in the golgi point proteins depending on their function. This is the sorting of the proteins. Once sorted, golgi enzymes modify the proteins. Golgi enzymes methylate, demethylate, add phosphate, etc to make sure that they are what they should be depending on what the proteins need to do. Once modified, they leave through the trans exit. When proteins leave the golgi, they are in their permanent vesicle coating. Now the proteins go to wherever their function is. Rer lumen lysosomes golgi (through cis opening) lysosomes sort .

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