BSC 114 Chapter Notes - Chapter 2-6: Lysosome, Exocytosis
Endomembrane System
● Endoplasmic Reticulum
○ Transports proteins and lipids
○ Smooth ER
■ No ribosomes
■ Site of lipid synthesis
○ Rough ER
■ Has ribosomes
● Think about proteins
● Site of protein synthesis
■ Proteins exit the RER out of the lumen via Exocytosis
● Lumen forms a vesicle that provides an exit for the proteins
■ Lysosomes then take charge and direct the proteins once out of the RER
● Lysosomes
○ Carry out a couple of functions
○ Directing proteins
■ “Safety patrol”
○ After proteins exit the RER, lysosomes take charge
○ Point proteins to the Golgi cis opening
■ Cis: front or beginning
● Golgi Apparatus
○ Most jobs of any
○ Sorts, modifies, and packages proteins
○ Proteins enter golgi via endocytosis
○ Once inside, lysosomes in the golgi point proteins depending on their function
■ This is the sorting of the proteins
○ Once sorted, golgi enzymes modify the proteins
■ Golgi enzymes methylate, demethylate, add phosphate, etc to make sure
that they are what they should be depending on what the proteins need to
do
○ Once modified, they leave through the trans exit
■ Exit via exocytosis
■ When proteins leave the golgi, they are in their permanent vesicle coating
○ Now the proteins go to wherever their function is
● Whole process
○ RER → Lumen → Lysosomes → Golgi (through cis opening) → Lysosomes sort →
Enzymes modify → Packaged → leave golgi → goes to their various functions
●
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Document Summary
Proteins exit the rer out of the lumen via exocytosis. Lumen forms a vesicle that provides an exit for the proteins. Lysosomes then take charge and direct the proteins once out of the rer. After proteins exit the rer, lysosomes take charge. Point proteins to the golgi cis opening. Once inside, lysosomes in the golgi point proteins depending on their function. This is the sorting of the proteins. Once sorted, golgi enzymes modify the proteins. Golgi enzymes methylate, demethylate, add phosphate, etc to make sure that they are what they should be depending on what the proteins need to do. Once modified, they leave through the trans exit. When proteins leave the golgi, they are in their permanent vesicle coating. Now the proteins go to wherever their function is. Rer lumen lysosomes golgi (through cis opening) lysosomes sort .