PSY 358 Chapter Notes - Chapter 11: Proteasome Inhibitor, Insulin-Like Growth Factor 2, Anisomycin

• School: Stony Brook University
• Department: Psychology
• Course: PSY 358
• Professor: ryan parsons

Document Summary

A labile stm trace gives way to stable ltm. Short term phase: shortly after an experience, memory retrieval is supported by an active short-term trace, stm active state rapid decay vulnerable to disruption, **diagram**-slide 17. Long term phase: as stm trace decays, a more stable, long-term memory trace is generated that can support memory retrieval for a much longer period of time, ltm inactive state slow decay less vulnerable to disruption, **diagram**-slide 18. This result is consistent with the hypothesis that mx contributes to both short-term and long-term memory but is also consistent with other interpretations. [the drug does effect the retention interval over a period of time] Transcription and enduring memories: creb: long-lasting ltp initiates both local translation and genomic signaling which both lead to new proteins being made. C/ebp-beta and memory consolidation (a) increased levels of phosphorylated creb (pcreb) are present in the hippocampus shortly after training and remain high for at least 20 hours.