BIOL 1101 Chapter Notes - Chapter 19: Open Reading Frame, Chromatin Remodeling, Rna Splicing
3 Dec 2016
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Document Summary
Epigenetic changes can in some cases alter gene expression and can be passed on from parent to child: imprinting= sex-speci c silencing of gene expression. Xic= x chromosome inactivation center, contains a gene called xist (x- inactivation speci c transcript) Transcription is a key control point in gene expression. Sunday, november 13, 2016: transcriptional regulation= mechanisms that regulate whether or not transcription occurs. General transcription factors= important group of proteins, recruited to the gene"s promoter. Small regulatory rnas inhibit translation or promote mrna degradation: small regulatory rnas= regulatory rna molecules. Sirna (small interfering rna) + mirna (microrna)= transcribed from dna, form hairpin structures (stem-and-loops) stabilized by base pairing in the stem. Enzymes in cytoplasm recognize these structures > cleave them from hairpin . Physical contact creates loop in mrna > brings 3" end of mrna into proximity with start site for translation. Most mrna sequence that regulate translation are in the 3" utr.
