BIOL 1201 Chapter : Structure Of Nucleotide Strand

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15 Mar 2019
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Dna (deoxyribonucleic acid) and rna (ribonucleic acid) are polymers of nucleotides linked in a chain through phosphodiester bonds. In biological systems, they serve as information-carrying molecules or, in the case of some rna molecules, catalysts. This brief review will focus on aspects of structure of particular importance in manipulating dna. Nucleotides are the building blocks of all nucleic acids. Nucleotides have a distinctive structure composed of three components covalently bound together: a nitrogen-containing "base" - either a pyrimidine (one ring) or purine (two rings, a 5-carbon sugar - ribose or deoxyribose, a phosphate group. The combination of a base and sugar is called a nucleoside. Nucleotides also exist in activated forms containing two or three phosphates, called nucleotide diphosphates or triphosphates. If the sugar in a nucleotide is deoxyribose, the nucleotide is called a deoxynucleotide; if the sugar is ribose, the term ribonucleotide is used. The structure of a nucleotide is depicted below.

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