BIOL 1001 Chapter : Biol 1001 Chap12
Document Summary
Suggested that some metabolic disorders were caused by a blocked. These inherited disorders were the result of the lack of an enzyme. Dna is the instructions (program) that tells the cell what to do. >>>>>>the study of metabolic defects provided evidence that genes lead to proteins. This relationship was first proposed by archibald garrod in 1909. A blockage in a pathway not only stops the production of something we need but it also may lead to the accumulation of something we don"t want. (see fig e12-1) The suggestion of garrod were confirmed in the 1930"s. George beadle and edward tatum conducted experiment with bread mold, Neurospora crassa, and demonstrated that different mutants (generated by. X-rays) had the pathway of arginine (an amino acid) synthesis blocked at different steps. (see fig e12-1) Wild-type bread mold could survive on minimal medium. Beadle and tatum deduced that the 3 different mutant types each lacked a different enzyme in the pathway which synthesizes arginine.
