BIOL 1001 Chapter : Ch 12
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Suggested that some metabolic disorders were caused by a blocked pathway. These inherited disorders were the result of the lack of an enzyme. Dna is the instructions (program) that tells the cell what to do. >>>>>>the study of metabolic defects provided evidence that genes lead to proteins. This relationship was first proposed by archibald garrod in 1909. A blockage in a pathway not only stops the production of something we need but it also may lead to the accumulation of something we don"t want. (see fig e12-1) The suggestion of garrod were confirmed in the 1930"s. George beadle and edward tatum conducted experiment with bread mold, neurospora crassa, and demonstrated that different mutants (generated by x-rays) had the pathway of arginine (an amino acid) synthesis blocked at different steps. (see fig e12-1) Wild-type bread mold could survive on minimal medium.
