NURS 3331 Chapter Notes - Chapter 71: Colorectal Cancer, Postpartum Bleeding, Ace Inhibitor
Document Summary
Inhibit cyclooxygenase (cox), the enzyme that converts arachidonic acid into prostanoids (prostaglandins and related compounds) Protection against myocardial infarction (mi) and stroke o. Inhibition of cox-2 ( bad cox ): largely beneficial effects: Used to treat inflammatory disorders (rheumatoid arthritis, osteoarthritis, bursitis) o o o. Suppress inflammation but pose risk of serious harm. Suppression of platelet aggregation o o o o o o o o o o o o o o o. Salicylism: tinnitus (ringing in the ears), sweating, headache, and dizziness. Aspirin -like drugs with fewer gi, renal, and hemorrhagic effects than aspirin. 20+ nonaspirin nsaids available (all similar, but for unknown reasons, patients tend to do better on one drug or another) Inhibit cox -1 and cox -2: inhibition is reversible (unlike with aspirin) Ibuprofen [advil, motrin] o o o o o. Inhibits cyclooxygenase and has antiinflammatory, analgesic, and antipyretic actions.
