PAT 20A/B Study Guide - Midterm Guide: Vitamin K Deficiency, Acute Kidney Injury, Rheumatoid Arthritis

• School: Ryerson University
• Department: Pathotherapeutics
• Course: PAT 20A/B
• Professor: Leo Michelis

Document Summary

Cox-1 inhibitors: more specific i(cid:374) targeti(cid:374)g the (cid:862)good prostagla(cid:374)di(cid:374)s(cid:863) inhibits platelet aggregation, effects on kidney & gastric mucosa. Cox-2 inhibitors: more specific in targeting inflammation and pain ( bad prostaglandins, cause fewer gi adverse effects than nsaids. Relieves pain by blocking the chemical activity of both or either enzymes cyclooxygenase ( pg. Most nsaids are cox-1 and cox-2 inhibitors --- blocks the (cid:862)good(cid:863) prostagla(cid:374)di(cid:374) and the (cid:862)bad(cid:863) prostaglandin ( thus blocks pain: cyclooxygenase converts arachidonic acid to prostaglandin, but if you inhibit it prostaglandin is not produced. Do not bind to opioid receptors ( non- opioid analgesic: can be used in the first 2 trimesters of pregnancy. Gi distress ** heart burn, gastrointestinal bleeding. Hypokalemia--- deficiency of potassium in the blood. Condition that place the patient at risk for bleeding. Conditions include rhinitis ( risk of nosebleed), vitamin k deficiency, and peptic ulcer disease. Not recommended during 3rd trimester of pregnancy excessive maternal bleeding, neonatal.