CAS BI 206 Chapter Notes - Chapter 7: Dna Repair, Dna Mismatch Repair, Dna Replication
11 Feb 2018
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Chapter 7: anatomy and function of a gene: dissection through mutation. Genes with one common allele monomorphic ; genes with multiple common alleles polymorphic. Wild-type alleles in polymorphic genes are hard to define common variants allele to different allele. Types of mutations novel/mutant allele to wild type allele. Transition purine purine (a/g) or pyrimidine pyrimidine (c/t) Transversion purine pyrimidine and vice versa deleted. Inversion 180 o rotation (ie, base pair(s) switch sides) Reciprocal translocations added portions of nonhomologous chromosomes swap places. Different genes have different mutations rates (varying size = varying chance of mutation) Rate of forward mutation > rate of reverse mutation (more things can be broken than can be fixed) Mutations are random; not caused by environmental changes/pressure. Depurination hydrolysis of purine (a/g); no complementary base random base opposite. Deamination removal of amino group; cytosine uracil. Radiation can break sugar backbone mutations and duplication. Methyl directed mismatch repair notices and fixes errors in replicated dna.
