PSC 432 Chapter 33: Quinolones
17 Feb 2019
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Document Summary
In general, they are effective against gram negative organisms such as the. Binding of the quinolone to both the enzyme and the dna forms a ternary complex that. Because dna gyrase is a bacteriospecific target for antimicrobial therapy, cross. The fluoroquinolones enter the bacterium by passive diffusion through porins in the outer. Once inside the cell, they inhibit the replication of bacterial dna by interfering with the. They are effective in the treatment of gonorrhea but not syphilis. Bactericidal activity becomes more pronounced as the serum drug concentration increases to approximately thirty fold the minimum inhibitory concentration. Enterobacteriacae, pseudomonas spp, h. influenzae, m catarrhalis, legionellaceae, chlamydia, and mycobacteria. pneumoniae. gram-negative rods, and only used in uncomplicated utis fluoroquinolones exhibit significant intracellular penetration (for example, chlamydia, mycoplasma, and legionella). G+ cocci, g+ rod; b. anthracis, g- rods, g- coccus; n. gonnorhoeae and mycoplasma and chlamydiae. 3rd generation; increased activity against gram-positives (including s. pneumoniae) and atypicals.
