NURS 3110 Lecture Notes - Lecture 21: Antimetabolite, Bactericide, Diazepam
Document Summary
Quinolones, rifampin, metronidazole & sulfonamides: target dna/rna. Remember the 5fs: feces transferred to food, fingers, flies and some fomites: any object that acts as a carrier of disease: resistance, s. aureus, n. gonorrhoeae, e. coli, many healthcare providers do not understand fecal-oral contamination. 9/11: gemifloxacin (factive, levofloxacin (levaquin, moxifloxacin (avelox, norfloxacin (noroxin, ofloxacin (floxin, mostly given oral, can give iv, when given intravenously, rapid intravenous injection may produce hypotension. Indications: anthrax (prophylaxis and treatment, bone infections, gi tract, pid, pneumonia, skin infections, urinary tract, currently, none of the first-generation quinolones are produced are marketed. You"ll see that norfloxacin concentrates in the urinary tract, and ciprofloxacin and ofloxacin have greater systemic penetration: the remainder of the commercially available fluoroquinolones are in the 3rd and 4th generations. It can originate from otherwise benign crops such as alfalfa or clover. Interaction with dna results in structure defects: nucleic acid inhibition, metronidazole is an antibiotic and antiprotazoal.
