PHIL 2015 Chapter Notes - Chapter 3.1: Ulcerative Colitis, Nod2, Abdominal Pain
23 May 2020
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= so equals an interplay of a lot of factors. *so they get t cell activation (acute inflammation) and then this switch gets turned off and you cant turn it off chronic inflammation & cant turn it off! * majority of people have disease in colon or ileum. (crohsn)s. for uc patients, inflammation starts in colon and then moves proximally. So in uc see continuous inflammation whereas in crohsn see skip lesions (non-continuous_ Crohns disease is transmural (through all the laeyers) * so can get deep ulcers and creeping fat in crohns. Inflammatory mass rlq: abdominal pain, diarrhea, obstructure (usually partial, weight loss, fever, perianal disease (photo) Ulcerative colitis: common clinical manifestations: abdominal pain, diarrhea, frequent, small volume, **small bowel diarrhea is usually less frequent, but more volume, whereas colitis (large bowel issues) diarrhea, is more frequent, but small volume, rectal bleeding, mucous. Used to be you died of this, but now managed better. (google this?)
