KINE 4370 Chapter Notes - Chapter 12: Randomized Controlled Trial, Major Depressive Episode, Cognitive Therapy
21 Dec 2017
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Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence (prevent): a randomised controlled trial. Abstract: individuals with a history of recurrent depression have a high risk of repeated depressive relapse or recurrence. Maintenance antidepressants for at least 2 years is the current recommended treatment, but many individuals are interested in alternatives to medication. Mindfulness-based cognitive therapy (mbct) has been shown to reduce risk of relapse or recurrence compared with usual care, but has not yet been compared with maintenance antidepressant treatment in a definitive trial. We aimed to see whether mbct with support to taper or discontinue antidepressant treatment (mbct-ts) was superior to maintenance antidepressants for prevention of depressive relapse or recurrence over 24 months. Participants were randomly assigned to either mbct-ts or maintenance antidepressants (in a 1:1 ratio) with a computer-generated random number sequence with stratification by centre and symptomatic status.
