BIOL 3120 Chapter Notes -Mhc Class I, B Cell, Polyclonal Antibodies
Document Summary
9: down regulation of mhc i expression and mutation in any of the genese involved in ag processing (ex. Genes coding for tap: the up-regulation of anti-apoptotic mediators and the expression of mutated or absent death receptors, poor costimulatory signals. 10: chemotherapies aimed at blocking dna synthesis and cell division, hormonal therapies which interfere with tumor cell growth, targeted therapies such as small molecule inhibitors of cancer cells. Immunotherapies that induce or enhance anti-cancer immune response. Polyclonal antibodies: mixture of different antibodies targeted toward variety of epitopes. Monoclonal antibodies: product of a single b cell. Normal b cell + myeloma cell => hybridoma (growth properties of myeloma while containing unique antibody of parent b cell) Inject secreted antibodies from hybridoma to mouse: selection for target antibodies.
